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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   PDCD6 Antibody (N-term)   

PDCD6 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - PDCD6 Antibody (N-term) AP19928a
    PDCD6 Antibody (N-term) (Cat. #AP19928a) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PDCD6 antibody detected the PDCD6 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O75340
Other Accession NP_037364.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 21868 Da
Antigen Region 19-47 aa
Additional Information
Gene ID 10016
Other Names Programmed cell death protein 6, Apoptosis-linked gene 2 protein, Probable calcium-binding protein ALG-2, PDCD6, ALG2
Target/Specificity This PDCD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the N-terminal region of human PDCD6.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPDCD6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PDCD6
Synonyms ALG2
Function Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphoprylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extend, isoform 2, can stabilize SHISA5.
Cellular Location Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Endosome. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules
Research Areas
Citations (0)

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This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.


Vergarajauregui, S., et al. J. Biol. Chem. 284(52):36357-36366(2009)
Okumura, M., et al. Biochem. Biophys. Res. Commun. 386(1):237-241(2009)
Suzuki, H., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 (PT 11), 974-977 (2008) :
Yamada, Y., et al. Cancer Sci. 99(11):2193-2199(2008)
Suzuki, H., et al. Structure 16(10):1562-1573(2008)

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$ 295.00
$ 99.00
Cat# AP19928a
(40 western blots)
Availability: In Stock
Bulk Size
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