|Application ||WB, E|
|Calculated MW||21868 Da|
|Antigen Region||19-47 aa|
|Other Names||Programmed cell death protein 6, Apoptosis-linked gene 2 protein, Probable calcium-binding protein ALG-2, PDCD6, ALG2|
|Target/Specificity||This PDCD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-47 amino acids from the N-terminal region of human PDCD6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDCD6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-binding protein required for T-cell receptor-, Fas-, and glucocorticoid-induced cell death. May mediate Ca(2+)- regulated signals along the death pathway (By similarity). Calcium-dependent adapter necessary for the association between PDCD6IP and TSG101. Interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity. May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway. Seems to play a role in the regulation of the distribution and function of MCOLN1 in the endosomal pathway. Isoform 2 has a lower Ca(2+) affinity than isoform 1. Isoform 1 and, to a lesser extent, isoform 2, can stabilize SHISA5.|
|Cellular Location||Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein Nucleus. Endosome. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a calcium-binding protein belonging to the penta-EF-hand protein family. Calcium binding is important for homodimerization and for conformational changes required for binding to other protein partners. This gene product participates in T cell receptor-, Fas-, and glucocorticoid-induced programmed cell death. In mice deficient for this gene product, however, apoptosis was not blocked suggesting this gene product is functionally redundant.
Vergarajauregui, S., et al. J. Biol. Chem. 284(52):36357-36366(2009)
Okumura, M., et al. Biochem. Biophys. Res. Commun. 386(1):237-241(2009)
Suzuki, H., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 64 (PT 11), 974-977 (2008) :
Yamada, Y., et al. Cancer Sci. 99(11):2193-2199(2008)
Suzuki, H., et al. Structure 16(10):1562-1573(2008)
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