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TIAM1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - TIAM1 Antibody (C-term) AP19942b
    TIAM1 Antibody (C-term) (Cat. #AP19942b) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the TIAM1 antibody detected the TIAM1 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q13009
Other Accession Q60610, NP_003244.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 177508 Da
Antigen Region 1478-1506 aa
Additional Information
Gene ID 7074
Other Names T-lymphoma invasion and metastasis-inducing protein 1, TIAM-1, TIAM1
Target/Specificity This TIAM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1478-1506 amino acids from the C-terminal region of human TIAM1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTIAM1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TIAM1
Function Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.
Cellular Location Cell junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Detected at the boundary between cells with actin-rich protrusions (By similarity) Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.
Tissue Location Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas
Research Areas
Citations (0)

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Background

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.

References

Yang, W., et al. Jpn. J. Clin. Oncol. 40(11):1053-1059(2010)
Moriarty, C.H., et al. J. Biol. Chem. 285(27):20541-20546(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Rajagopal, S., et al. J. Biol. Chem. 285(23):18060-18071(2010)
Shepherd, T.R., et al. J. Mol. Biol. 398(5):730-746(2010)

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Cat# AP19942b
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(40 western blots)
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