|Application ||WB, E|
|Calculated MW||165538 Da|
|Antigen Region||679-707 aa|
|Other Names||Synaptojanin-2, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 2, SYNJ2, KIAA0348|
|Target/Specificity||This SYNJ2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 679-707 amino acids from the Central region of human SYNJ2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SYNJ2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis.|
|Cellular Location||Membrane. Note=Predominantly associated with the particulate fractions.|
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Provided below are standard protocols that you may find useful for product applications.
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants.
Rikova, K., et al. Cell 131(6):1190-1203(2007)
Ieguchi, K., et al. J. Biol. Chem. 282(32):23296-23305(2007)
Rossi, M.R., et al. Cancer Genet. Cytogenet. 161(2):97-103(2005)
Chuang, Y.Y., et al. Cancer Res. 64(22):8271-8275(2004)
Spaenij-Dekking, E.H., et al. Leukemia 17(12):2467-2473(2003)
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