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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   BMPR1A Antibody (N-term K36)   

BMPR1A Antibody (N-term K36)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - BMPR1A Antibody (N-term K36) AP2004C
    Western blot analysis of anti-BMPR1A Antibody (N-term K36)(Cat.#AP2004c) in 293 cell line lysates (35ug/lane). BMPR1A(arrow) was detected using the purified Pab.
  • IF - BMPR1A Antibody (N-term K36) AP2004C
    Confocal immunofluorescent analysis of BMPR1A Antibody (N-term K36)(Cat#AP2004c) with 293 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P36894
Other Accession NP_004320
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 60198 Da
Antigen Region 21-51 aa
Additional Information
Gene ID 657
Other Names Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3
Target/Specificity This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-51 amino acids from the N-terminal region of human BMPR1A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsBMPR1A Antibody (N-term K36) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms ACVRLK3, ALK3
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4. Positively regulates chondrocyte differentiation through GDF5 interaction (By similarity).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Highly expressed in skeletal muscle.
Research Areas
Citations (0)

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The bone morphogenetic protein (BMP) receptors belong to a family of transmembrane serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. Both activins and TGF-beta transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMP receptors are highly expressed in bone, skeletal muscle, heart and liver tissue. BMPRs play a crucial role during development as mutations or deletions to the BMPR genes can cause juvenile polyposis, disrupt normal dorsal/ventral patterning during limb development, and may be a factor in the progession of Cowden-like syndrome. Germline mutations in the BMPR2 gene encoding bone morphogenetic protein (BMP) type II receptor (BMPR-II) have been reported in patients with primary pulmonary hypertension (PPH).


Zhou, X.-P., et al., Am. J. Hum. Genet. 69(4):704-711 (2001).
Howe, J.R., et al., Nat. Genet. 28(2):184-187 (2001).
ten Dijke, P., et al., Oncogene 8(10):2879-2887 (1993).

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Cat# AP2004C
(40 western blots)
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