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BMPR1A Antibody (Center C180)Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
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| Catalog # | Size | Availability | Price | |
| AP2004d | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
- Protocols
- Backgrounds
BMPR1A Antibody (Center C180) - Product info | |
| Application | WB
|
| Primary Accession | P36894 |
| Reactivity | Human, Mouse |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 60198 Da |
BMPR1A Antibody (Center C180) - Additional info | |
| Gene ID 657 | |
| Other Names BMPR1A; ACVRLK3; ALK3; Bone morphogenetic protein receptor type-1A; Activin receptor-like kinase 3; Serine/threonine-protein kinase receptor R5; CD_antigen=CD292; Flags: Precursor | |
| Target/Specificity This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173~202 amino acids from the central region of human BMPR1A. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions BMPR1A Antibody (Center C180) is for research use only and not for use in diagnostic or therapeutic procedures. | |
BMPR1A Antibody (Center C180) - Protein Information | |
| Name BMPR1A | |
| Synonyms ACVRLK3, ALK3 | |
| Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4 | |
| Cellular Location Membrane; Single-pass type I membrane protein | |
| Tissue Location Highly expressed in skeletal muscle. | |
BMPR1A Antibody (Center C180) - Related products
AP2004a: BMPR1A Antibody (N-term)
AP2004b: BMPR1A Antibody (C-term)
AP2004c: BMPR1A Antibody (N-term K36)
AP2004d: BMPR1A Antibody (Center C180)
AP2004e: BMPR1A Antibody (N-term)
AP2004f: BMPR1A Antibody (N-term)
RI10618: BMPR1A predesign siRNA
DC05829: Human BMPR1A cDNA Clone
LY11707a: BMPR1A Over-expression Lysate
BP2004a: BMPR1A Antibody (N-term) Blocking Peptide
BP2004b: BMPR1A Antibody (C-term) Blocking Peptide
BP2004c: BMPR1A Antibody (N-term K36) Blocking Peptide
BP2004d: BMPR1A Antibody (Center C180) Blocking Peptide
BP2004e: BMPR1A Antibody (N-term) Blocking Peptide
BMPR1A Antibody (Center C180) - Application data
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BMPR1A -C180 (Cat. #AP2004d) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the BMPR1A antibody detected the BMPR1A protein (arrow).
BMPR1A Antibody (Center C180) - Research Areas
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BACKGROUND
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
REFERENCES
Zhou, X.-P., et al., Am. J. Hum. Genet. 69(4):704-711 (2001). Howe, J.R., et al., Nat. Genet. 28(2):184-187 (2001). ten Dijke, P., et al., Oncogene 8(10):2879-2887 (1993).
