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SEC11A Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P67812 |
| Other Accession | P0C7V7, P42667, Q9R0P6, P67810, NP_055115.1 |
| Reactivity | Human |
| Predicted | Bovine, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 20625 Da |
| Antigen Region | 95-123 aa |
| Gene ID | 23478 |
|---|---|
| Other Names | Signal peptidase complex catalytic subunit SEC11A, Endopeptidase SP18, Microsomal signal peptidase 18 kDa subunit, SPase 18 kDa subunit, SEC11 homolog A, SEC11-like protein 1, SPC18, SEC11A, SEC11L1, SPC18, SPCS4A |
| Target/Specificity | This SC11A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-123 amino acids from the Central region of human SC11A. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SEC11A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SEC11A |
|---|---|
| Synonyms | SEC11L1, SPC18, SPCS4A |
| Function | Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N- terminal signal peptides that contain a hydrophobic alpha-helix (h- region) shorter than 18-20 amino acids (PubMed:34388369). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P67811}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P67811} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity).
References
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Dodson, G., et al. Curr. Opin. Struct. Biol. 8(2):189-194(1998)
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