GLUD2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P49448 |
Other Accession | NP_036216.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 61434 Da |
Antigen Region | 75-103 aa |
Gene ID | 2747 |
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Other Names | Glutamate dehydrogenase 2, mitochondrial, GDH 2, GLUD2, GLUDP1 |
Target/Specificity | This GLUD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-103 amino acids from the N-terminal region of human GLUD2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GLUD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GLUD2 |
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Synonyms | GLUDP1 |
Function | Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission. |
Cellular Location | Mitochondrion matrix |
Tissue Location | Expressed in retina, testis and, at a lower level, brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.
References
Spanaki, C., et al. J. Biol. Chem. 285(22):16748-16756(2010)
Plaitakis, A., et al. Eur. J. Hum. Genet. 18(3):336-341(2010)
Zaganas, I., et al. Neurochem. Int. 55 (1-3), 52-63 (2009) :
Mastorodemos, V., et al. Biochem. Cell Biol. 87(3):505-516(2009)
Kanavouras, K., et al. J. Neurochem. 109 SUPPL 1, 167-173 (2009) :
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