|Application ||WB, E|
|Calculated MW||61434 Da|
|Antigen Region||75-103 aa|
|Other Names||Glutamate dehydrogenase 2, mitochondrial, GDH 2, GLUD2, GLUDP1|
|Target/Specificity||This GLUD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 75-103 amino acids from the N-terminal region of human GLUD2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GLUD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission.|
|Cellular Location||Mitochondrion matrix|
|Tissue Location||Expressed in retina, testis and, at a lower level, brain|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is localized to the mitochondrion and acts as a homohexamer to recycle glutamate during neurotransmission. The encoded enzyme catalyzes the reversible oxidative deamination of glutamate to alpha-ketoglutarate. This gene is intronless.
Spanaki, C., et al. J. Biol. Chem. 285(22):16748-16756(2010)
Plaitakis, A., et al. Eur. J. Hum. Genet. 18(3):336-341(2010)
Zaganas, I., et al. Neurochem. Int. 55 (1-3), 52-63 (2009) :
Mastorodemos, V., et al. Biochem. Cell Biol. 87(3):505-516(2009)
Kanavouras, K., et al. J. Neurochem. 109 SUPPL 1, 167-173 (2009) :
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