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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Txnip Antibody (Center)   

Mouse Txnip Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Txnip Antibody (Center) AP20130c
    Mouse Txnip Antibody (Center) (Cat. #AP20130c) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Mouse Txnip antibody detected the Mouse Txnip protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8BG60
Other Accession Q5M7W1, NP_001009935.1
Reactivity Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 44363 Da
Antigen Region 116-145 aa
Additional Information
Gene ID 56338
Other Names Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1, Txnip, Vdup1
Target/Specificity This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Txnip Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Txnip
Synonyms Vdup1
Function May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.
Cellular Location Cytoplasm.
Tissue Location Ubiquitously expressed.
Research Areas
Citations (0)

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Background

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

References

Kwon, H.J., et al. Toxicol. Appl. Pharmacol. 248(3):277-284(2010)
Kwon, H.J., et al. J. Immunol. 185(7):3980-3989(2010)
Ren, Y., et al. FEBS Lett. 584(15):3480-3485(2010)
Chutkow, W.A., et al. Diabetes 59(6):1424-1434(2010)
Shao, Y., et al. Immunol. Lett. 129(2):78-84(2010)

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$ 295.00
$ 99.00
Cat# AP20130c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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