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Mouse Txnip Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q8BG60 |
| Other Accession | Q5M7W1, NP_001009935.1 |
| Reactivity | Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44363 Da |
| Antigen Region | 116-145 aa |
| Gene ID | 56338 |
|---|---|
| Other Names | Thioredoxin-interacting protein, Vitamin D3 up-regulated protein 1, Txnip, Vdup1 |
| Target/Specificity | This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip. |
| Dilution | WB~~1:2000 IHC-P~~1:100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Txnip Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Txnip |
|---|---|
| Synonyms | Vdup1 |
| Function | May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. |
| Cellular Location | Cytoplasm. |
| Tissue Location | Ubiquitously expressed. |
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Provided below are standard protocols that you may find useful for product applications.
Background
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.
References
Kwon, H.J., et al. Toxicol. Appl. Pharmacol. 248(3):277-284(2010)
Kwon, H.J., et al. J. Immunol. 185(7):3980-3989(2010)
Ren, Y., et al. FEBS Lett. 584(15):3480-3485(2010)
Chutkow, W.A., et al. Diabetes 59(6):1424-1434(2010)
Shao, Y., et al. Immunol. Lett. 129(2):78-84(2010)
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