|Application ||WB, E|
|Calculated MW||17999 Da|
|Antigen Region||138-167 aa|
|Other Names||Iron-sulfur cluster assembly enzyme ISCU, mitochondrial, NifU-like N-terminal domain-containing protein, NifU-like protein, ISCU, NIFUN|
|Target/Specificity||This ISCU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-167 amino acids from the C-terminal region of human ISCU.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ISCU Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the assembly or repair of the [Fe-S] clusters present in iron-sulfur proteins. Binds iron.|
|Cellular Location||Isoform 1: Mitochondrion.|
|Tissue Location||Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Iron-sulfur (Fe-S) clusters are necessary for several mitochondrial enzymes and other subcellular compartment proteins. They contain sulfur and iron, and are created via several steps that include cysteine desulfurases, iron donors, chaperones, and scaffold proteins. This gene encodes the two isomeric forms, ISCU1 and ISCU2, of the Fe-S cluster scaffold protein. Mutations in this gene have been found in patients with myopathy with severe exercise intolerance and myoglobinuria.
Chen, Z., et al. Oncogene 29(30):4362-4368(2010)
Chan, S.Y., et al. Cell Metab. 10(4):273-284(2009)
Kollberg, G., et al. Brain 132 (PT 8), 2170-2179 (2009) :
Huang, J., et al. J. Biol. Inorg. Chem. 13(5):825-836(2008)
Mochel, F., et al. Am. J. Hum. Genet. 82(3):652-660(2008)
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