|Application ||WB, E|
|Other Accession||P47819, P03995, Q28115, NP_002046|
|Calculated MW||49880 Da|
|Antigen Region||381-410 aa|
|Other Names||Glial fibrillary acidic protein, GFAP, GFAP|
|Target/Specificity||This GFAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-410 amino acids from the C-terminal region of human GFAP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GFAP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.|
|Cellular Location||Cytoplasm. Note=Associated with intermediate filaments|
|Tissue Location||Expressed in cells lacking fibronectin.|
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Provided below are standard protocols that you may find useful for product applications.
GFAP is one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system.
Quintanar, J.L., et al., Parasitol. Res. 90(4):261-263 (2003).
Shiroma, N., et al., Brain Dev. 25(2):116-121 (2003).
Nielsen, A.L., et al., J. Biol. Chem. 277(33):29983-29991 (2002).
Namekawa, M., et al., Ann. Neurol. 52(6):779-785 (2002).
Lopez-Egido, J., et al., Exp. Cell Res. 278(2):175-183 (2002).
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