|Application ||WB, E|
|Other Accession||Q99JI4, Q9V3G7, Q3T0B2, NP_055629.1|
|Predicted||Bovine, Drosophila, Mouse|
|Calculated MW||45531 Da|
|Antigen Region||154-182 aa|
|Other Names||26S proteasome non-ATPase regulatory subunit 6, 26S proteasome regulatory subunit RPN7, 26S proteasome regulatory subunit S10, Breast cancer-associated protein SGA-113M, Phosphonoformate immuno-associated protein 4, Proteasome regulatory particle subunit p44S10, p42A, PSMD6, KIAA0107, PFAAP4|
|Target/Specificity||This PSMD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-182 amino acids from the Central region of human PSMD6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PSMD6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair.|
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Provided below are standard protocols that you may find useful for product applications.
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
Tanaka, T., et al. Am. J. Hum. Genet. 84(4):477-482(2009)
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Listovsky, T., et al. EMBO J. 23(7):1619-1626(2004)
Bouwmeester, T., et al. Nat. Cell Biol. 6(2):97-105(2004)
Margottin-Goguet, F., et al. Dev. Cell 4(6):813-826(2003)
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