|Application ||WB, IHC-P, E|
|Other Accession||P62634, P53996, O42395, Q3T0Q6, NP_001120665.1|
|Predicted||Bovine, Chicken, Mouse|
|Calculated MW||19463 Da|
|Antigen Region||91-118 aa|
|Other Names||Cellular nucleic acid-binding protein, CNBP, Zinc finger protein 9, CNBP, RNF163, ZNF9|
|Target/Specificity||This CNBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-118 amino acids from the Central region of human CNBP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNBP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Single-stranded DNA-binding protein, with specificity to the sterol regulatory element (SRE). Involved in sterol-mediated repression.|
|Cellular Location||Cytoplasm. Endoplasmic reticulum|
|Tissue Location||Present in all tissues examined.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Catalli, C., et al. J Mol Diagn 12(5):601-606(2010)
Massa, R., et al. Neuropathol. Appl. Neurobiol. 36(4):275-284(2010)
Sammons, M.A., et al. PLoS ONE 5 (2), E9301 (2010) :
Lucchiari, S., et al. J. Neurol. Sci. 275 (1-2), 159-163 (2008) :
Auvinen, S., et al. Arthritis Rheum. 58(11):3627-3631(2008)
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