|Application ||WB, IHC-P, E|
|Calculated MW||107113 Da|
|Antigen Region||634-663 aa|
|Other Names||MORC family CW-type zinc finger protein 3, Zinc finger CW-type coiled-coil domain protein 3, MORC3, KIAA0136, ZCWCC3|
|Target/Specificity||This MORC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 634-663 amino acids from the Central region of human MORC3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MORC3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism (PubMed:20501696). Sumoylated MORC3-NBs can also associate with PML-NBs (PubMed:20501696). Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity (PubMed:17332504). Binds RNA in vitro (PubMed:11927593). May be required for influenza A transcription during viral infection (PubMed:26202233).|
|Cellular Location||Nucleus, nucleoplasm Nucleus matrix. Nucleus, PML body. Note=Also found in PML-independent nuclear bodies. Localization to nuclear bodies is ATP-dependent|
|Tissue Location||Expressed in heart, placenta, skeletal muscle, brain, pancreas, lung, liver, but not kidney|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled coil domain.
Nagase T., et al. DNA Res. 2:167-174(1995).
Ota T., et al. Nat. Genet. 36:40-45(2004).
Hattori M., et al. Nature 405:311-319(2000).
Burkard T.R., et al. BMC Syst. Biol. 5:17-17(2011).
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