|Application ||WB, E|
|Calculated MW||47472 Da|
|Antigen Region||350-378 aa|
|Other Names||Leukocyte immunoglobulin-like receptor subfamily A member 3, CD85 antigen-like family member E, Immunoglobulin-like transcript 6, ILT-6, Leukocyte immunoglobulin-like receptor 4, LIR-4, Monocyte inhibitory receptor HM43/HM31, CD85e, LILRA3, ILT6, LIR4|
|Target/Specificity||This LILRA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-378 amino acids from the C-terminal region of human LILRA3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||LILRA3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS- induced TNF-alpha production by monocytes.|
|Tissue Location||Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung.|
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Provided below are standard protocols that you may find useful for product applications.
May act as soluble receptor for class I MHC antigens.
Zhang Z., et al. Protein Sci. 13:2819-2824(2004).
Arm J.P., et al. J. Immunol. 159:2342-2349(1997).
Borges L., et al. J. Immunol. 159:5192-5196(1997).
Norman P.J., et al. Immunogenetics 55:165-171(2003).
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