|Application ||WB, IHC-P, E|
|Other Accession||P43114, Q28691, P32240, Q8MJ08|
|Predicted||Rat, Rabbit, Bovine|
|Calculated MW||53119 Da|
|Antigen Region||242-269 aa|
|Other Names||Prostaglandin E2 receptor EP4 subtype, PGE receptor EP4 subtype, PGE2 receptor EP4 subtype, Prostanoid EP4 receptor, PTGER4, PTGER2|
|Target/Specificity||This PTGER4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-269 amino acids from the Central region of human PTGER4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PTGER4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Bastien L., et al. J. Biol. Chem. 269:11873-11877(1994).
An S., et al. Biochem. Biophys. Res. Commun. 197:263-270(1993).
Foord S.M., et al. Genomics 35:182-188(1996).
Mori K., et al. J. Mol. Med. 74:333-336(1996).
Kopatz S.A., et al. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
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