|Application ||WB, IHC-P, E|
|Other Accession||Q80Z60, Q10711|
|Calculated MW||99773 Da|
|Antigen Region||551-579 aa|
|Other Names||Endothelin-converting enzyme 2, ECE-2, Methyltransferase-like region, 211-, Endothelin-converting enzyme 2 region, ECE2, KIAA0604|
|Target/Specificity||This ECE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the Central region of human ECE2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ECE2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein. Cytoplasmic granule membrane; Single-pass type II membrane protein|
|Tissue Location||Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.
Lorenzo M.-N., et al. Biochim. Biophys. Acta 1522:46-52(2001).
Funke-Kaiser H., et al. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Nagase T., et al. DNA Res. 5:31-39(1998).
Clark H.F., et al. Genome Res. 13:2265-2270(2003).
Muzny D.M., et al. Nature 440:1194-1198(2006).
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