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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SLUG Antibody (Center)   

SLUG Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - SLUG Antibody (Center) AP2053a
    All lanes : Anti-SLUG Antibody (Center) at 1:2000 dilution Lane 1: mouse heart lysate Lane 2: PC-12 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 30 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - SLUG Antibody (Center) AP2053a
    SLUG Antibody (Center) (Cat. #AP2053a) is used in Western blot to detect SLUG in mouse heart tissue lysate.
  • IHC-P - SLUG Antibody (Center) AP2053a
    Formalin-fixed and paraffin-embedded human Breast tissue reacted with SLUG Antibody (Center)(Cat.#AP2053a), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • IF - SLUG Antibody (Center) AP2053a
    Confocal immunofluorescent analysis of SLUG Antibody (Center) (Cat#AP2053a) with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43623
Other Accession Q3MHQ4
Reactivity Human, Mouse, Rat
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 29986 Da
Antigen Region 98-129 aa
Additional Information
Gene ID 6591
Other Names Zinc finger protein SNAI2, Neural crest transcription factor Slug, Protein snail homolog 2, SNAI2, SLUG, SLUGH
Target/Specificity This SLUG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-129 amino acids from the Central region of human SLUG.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSLUG Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNAI2
Synonyms SLUG, SLUGH
Function Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
Cellular Location Nucleus. Cytoplasm. Note=Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions
Tissue Location Expressed in most adult human tissues, including spleen, thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not detected in peripheral blood leukocyte. Expressed in the dermis and in all layers of the epidermis, with high levels of expression in the basal layers (at protein level). Expressed in osteoblasts (at protein level) Expressed in mesenchymal stem cells (at protein level). Expressed in breast tumor cells (at protein level)
Research Areas
Citations ( 0 )


SLUG is a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporadic cases of neural tube defects.


Sanchez-Martin, M., et al., Hum. Mol. Genet. 11(25):3231-3236 (2002). Hajra, K.M., et al., Cancer Res. 62(6):1613-1618 (2002). Hemavathy, K., et al., Mol. Cell. Biol. 20(14):5087-5095 (2000). Inukai, T., et al., Mol. Cell 4(3):343-352 (1999). Cohen, M.E., et al., Genomics 51(3):468-471 (1998).

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$ 295.00
$ 99.00
Cat# AP2053a
(40 western blots)
Availability: In Stock
Bulk Size
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