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Rat Atp1a1 Antibody (N-term S23)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P06685 |
| Reactivity | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 113054 Da |
| Gene ID | 24211 |
|---|---|
| Other Names | Sodium/potassium-transporting ATPase subunit alpha-1, Na(+)/K(+) ATPase alpha-1 subunit, Sodium pump subunit alpha-1, Atp1a1 |
| Target/Specificity | This Rat Atp1a1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from Rat Atp1a1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Rat Atp1a1 Antibody (N-term S23) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Atp1a1 |
|---|---|
| Function | This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (PubMed:30388404). Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:Q8VDN2}; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P05023}; Multi-pass membrane protein. Cell projection, axon Melanosome {ECO:0000250|UniProtKB:P05023} |
| Tissue Location | Expressed in the central nervous system, in most motor and sensory axons of the ventral and dorsal roots, as well as in the large motor neurons of the ventral horn (at protein level) |
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Provided below are standard protocols that you may find useful for product applications.
Background
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
References
Shull G.E.,et al.Biochemistry 25:8125-8132(1986).
Hara Y.,et al.J. Biochem. 102:43-58(1987).
Herrera V.L.M.,et al.J. Cell Biol. 105:1855-1865(1987).
Lubec G.,et al.Submitted (JUL-2007) to UniProtKB.
Schneider J.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:6357-6361(1985).
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