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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   PSEN2(Presenilin-2 CTF subunit) Antibody (C-term)   

PSEN2(Presenilin-2 CTF subunit) Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • IHC-P - PSEN2(Presenilin-2 CTF subunit) Antibody (C-term) AP20576c
    Immunohistochemical analysis of paraffin-embedded M.heart section using PSEN2(Presenilin-2 CTF subunit) Antibody (C-term)(Cat#AP20576c). AP20576c was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • IHC-P - PSEN2(Presenilin-2 CTF subunit) Antibody (C-term) AP20576c
    Immunohistochemical analysis of paraffin-embedded R.heart section using PSEN2(Presenilin-2 CTF subunit) Antibody (C-term)(Cat#AP20576c). AP20576c was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • IHC-P - PSEN2(Presenilin-2 CTF subunit) Antibody (C-term) AP20576c
    Immunohistochemical analysis of paraffin-embedded H.heart section using PSEN2(Presenilin-2 CTF subunit) Antibody (C-term)(Cat#AP20576c). AP20576c was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
  • WB - PSEN2(Presenilin-2 CTF subunit) Antibody (C-term) AP20576c
    Western blot analysis of lysates from Hela, MCF-7 cell line (from left to right), using PSEN2(Presenilin-2 CTF subunit) Antibody (C-term) (Cat. #AP20576c). AP20576c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession P49810
Other Accession O88777, Q0MS45, Q61144, Q9XT96
Reactivity Human
Predicted Bovine, Mouse, Pig, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 50140 Da
Additional Information
Gene ID 5664
Other Names Presenilin-2, PS-2, 3423-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2, AD4, PS2, PSNL2, STM2
Target/Specificity This PSEN2(Presenilin-2 CTF subunit) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 401-445 amino acids from the C-terminal region of human PSEN2(Presenilin-2 CTF subunit).
Dilution IHC-P~~1:25
WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsPSEN2(Presenilin-2 CTF subunit) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name PSEN2
Synonyms AD4, PS2, PSNL2, STM2
Function Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
Cellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
Tissue Location Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney
Research Areas
Citations (0)

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Background

Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.

References

Levy-Lahad E.,et al.Science 269:973-977(1995).
Rogaev E.I.,et al.Nature 376:775-778(1995).
Li J.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:12180-12184(1995).
Levy-Lahad E.,et al.Genomics 34:198-204(1996).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.

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$ 295.00
$ 99.00
Cat# AP20576c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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