|Application ||WB, IF, E|
|Calculated MW||117823 Da|
|Other Names||MORC family CW-type zinc finger protein 2, Zinc finger CW-type coiled-coil domain protein 1, MORC2, KIAA0852, ZCWCC1|
|Target/Specificity||This MORC2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 828-862 amino acids from the C-terminal region of human MORC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MORC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY, possibly preventing its dephosphorylation (PubMed:24286864). May act as a transcriptional repressor (PubMed:20225202). Down-regulates CA9 expression (PubMed:20110259).|
|Cellular Location||Nucleus. Cytoplasm, cytosol. Note=Mainly located in the nucleus|
|Tissue Location||Highly expressed in smooth muscle, pancreas and testis|
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Provided below are standard protocols that you may find useful for product applications.
May act as a transcriptional repressor. Down-regulates CA9 expression.
Nagase T.,et al.DNA Res. 5:355-364(1998).
Collins J.E.,et al.Genome Biol. 5:R84.1-R84.11(2004).
Dunham I.,et al.Nature 402:489-495(1999).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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