|Application ||WB, IHC-P, E|
|Calculated MW||39475 Da|
|Antigen Region||30-59 aa|
|Other Names||Embryonic growth/differentiation factor 1, GDF-1, GDF1|
|Target/Specificity||This GDF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human GDF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||GDF1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May mediate cell differentiation events during embryonic development.|
|Tissue Location||Expressed in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
GDF1 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right assymetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA which also encodes the longevity assurance gene.
Ducy, P., et al., Kidney Int. 57(6):2207-2214 (2000). Jiang, J.C., et al., Genome Res. 8(12):1259-1272 (1998). Polymeropoulos, M.H., et al., Nat. Genet. 4(4):381-386 (1993). Lee, S.J., Proc. Natl. Acad. Sci. U.S.A. 88(10):4250-4254 (1991).
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