Mouse Insrr Antibody (C-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9WTL4 |
Other Accession | Q64716 |
Reactivity | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 144875 Da |
Antigen Region | 1265-1295 aa |
Gene ID | 23920 |
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Other Names | Insulin receptor-related protein, IRR, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, Insrr, Irr |
Target/Specificity | This Mouse Insrr antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1265-1295 amino acids from the C-terminal region of Mouse Insrr. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | Mouse Insrr Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Insrr |
---|---|
Synonyms | Irr |
Function | Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB. |
Cellular Location | Membrane; Single-pass type I membrane protein |
Tissue Location | Highly expressed in the islets as well as in pancreatic beta-cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.
References
Hirayama I.,et al.Diabetes 48:1237-1244(1999).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Kitamura T.,et al.Mol. Cell. Biol. 21:5624-5630(2001).
Deyev I.E.,et al.Cell Metab. 13:679-689(2011).
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