|Application ||WB, E|
|Calculated MW||62304 Da|
|Other Names||Interleukin-18 receptor 1, IL-18R-1, IL-18R1, CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, IL-1Rrp, IL1R-rp, CD218a, IL18R1, IL1RRP|
|Target/Specificity||This IL18R1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 527-561 amino acids from the C-terminal region of human IL18R1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IL18R1Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Within the IL18 receptor complex, responsible for the binding of the proinflammatory cytokine IL18, but not IL1A nor IL1B (Probable) (PubMed:8626725). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
Parnet P.,et al.J. Biol. Chem. 271:3967-3970(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Hillier L.W.,et al.Nature 434:724-731(2005).
Torigoe K.,et al.J. Biol. Chem. 272:25737-25742(1997).
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