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IL18R1Antibody(C-term)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q13478 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 62304 Da |
| Gene ID | 8809 |
|---|---|
| Other Names | Interleukin-18 receptor 1, IL-18R-1, IL-18R1, CD218 antigen-like family member A, CDw218a, IL1 receptor-related protein, IL-1Rrp, IL1R-rp, CD218a, IL18R1, IL1RRP |
| Target/Specificity | This IL18R1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 527-561 amino acids from the C-terminal region of human IL18R1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | IL18R1Antibody(C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | IL18R1 (HGNC:5988) |
|---|---|
| Synonyms | IL1RRP |
| Function | Within the IL18 receptor complex, responsible for the binding of the pro-inflammatory cytokine IL18, but not IL1A nor IL1B (PubMed:14528293, PubMed:25261253, PubMed:25500532, PubMed:37993714, PubMed:8626725). Involved in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850). Contributes to IL18-induced cytokine production, either independently of SLC12A3, or as a complex with SLC12A3 (By similarity). |
| Cellular Location | Membrane; Single- pass type I membrane protein |
| Tissue Location | Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10653850, PubMed:10925275, PubMed:11046021). |
Research Areas
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$ 192.50
Cat# AP20911c
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