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> home > Products > Primary Antibodies > Antibody Collections > Immune system process > TRBC1 Antibody (Center)
TRBC1 Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | P01850 |
| Other Accession | A0A5B9 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 19769 Da |
| Antigen Region | 104-136 aa |
| Other Names | T-cell receptor beta-1 chain C region, TRBC1 |
|---|---|
| Target/Specificity | This TRBC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 104-136 amino acids from the Central region of human TRBC1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TRBC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TRBC1 {ECO:0000303|Ref.7} |
|---|---|
| Function | Constant region of T cell receptor (TR) beta chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen- activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa- B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:9382891, PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non- autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). |
| Cellular Location | Cell membrane. |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Yanagi Y.,et al.Nature 308:145-149(1984).
Tunnacliffe A.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:5068-5072(1985).
Rowen L.,et al.Science 272:1755-1762(1996).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).
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$ 365.00
$ 140.00
Cat# AP20913a
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