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SMG7 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SMG7 Antibody (C-term) AP20918c
    Western blot analysis of lysates from HT-29, Jurkat, MCF-7 cell line (from left to right), using SMG7 Antibody (C-term)(Cat. #AP20918c). AP20918c was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q92540
Other Accession Q5RJH6
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 127282 Da
Additional Information
Gene ID 9887
Other Names Protein SMG7, EST1-like protein C, SMG-7 homolog, hSMG-7, SMG7, C1orf16, EST1C, KIAA0250
Target/Specificity This SMG7 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 896-930 amino acids from the C-terminal region of human SMG7.
Dilution WB~~1:500-1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSMG7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMG7
Synonyms C1orf16, EST1C, KIAA0250
Function Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.
Cellular Location Cytoplasm. Nucleus. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm
Citations (0)

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Background

Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation.

References

Ohnishi T.,et al.Mol. Cell 12:1187-1200(2003).
Nagase T.,et al.DNA Res. 3:321-329(1996).
Nakajima D.,et al.DNA Res. 9:99-106(2002).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).

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$ 295.00
$ 99.00
Cat# AP20918c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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