|Application ||WB, E|
|Calculated MW||159157 Da|
|Other Names||Nuclear receptor coactivator 2, NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2, NCOA2, BHLHE75, SRC2, TIF2|
|Target/Specificity||This NCOA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1169-1203 amino acids from the C-terminal region of human NCOA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NCOA2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BHLHE75, SRC2, TIF2|
|Function||Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK- ARNTL/BMAL1 heterodimer (By similarity).|
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Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues.
Voegel J.J.,et al.EMBO J. 15:3667-3675(1996).
Carapeti M.,et al.Blood 91:3127-3133(1998).
Voegel J.J.,et al.EMBO J. 17:507-519(1998).
Fryer C.J.,et al.Nature 393:88-91(1998).
Carrero P.,et al.Mol. Cell. Biol. 20:402-415(2000).
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