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(DANRE) sh3bp4a Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - (DANRE) sh3bp4a Antibody (N-term) AP21084a
    Western blot analysis of lysate from ZF4 cell line, using DANRE sh3bp4a Antibody (N-term)(Cat. #AP21084a). AP21084a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q1LVQ2
Reactivity Zebrafish
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 108453 Da
Additional Information
Gene ID 403082
Other Names SH3 domain-binding protein 4-A, sh3bp4a, sh3bp4
Target/Specificity This DANRE sh3bp4a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 132-165 amino acids from the N-terminal region of DANRE sh3bp4a.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Precautions(DANRE) sh3bp4a Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name sh3bp4a
Synonyms sh3bp4
Function Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).
Cellular Location Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle Nucleus. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin- coated vesicles. May also localize to the nucleus (By similarity)
Research Areas
Citations (0)

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Background

Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).

References

Howe K.,et al.Nature 496:498-503(2013).
Abe S.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.

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$ 295.00
$ 99.00
Cat# AP21084a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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