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NACC1 Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - NACC1 Antibody (C-term) AP21107a
    Western blot analysis of lysate from mouse brain tissue lysate, using NACC1 Antibody (C-term)(Cat. #AP21107a). AP21107a was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q96RE7
Other Accession O35260, Q7TSZ8
Reactivity Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 57258 Da
Additional Information
Gene ID 112939
Other Names Nucleus accumbens-associated protein 1, NAC-1, BTB/POZ domain-containing protein 14B, NACC1, BTBD14B, NAC1
Target/Specificity This NACC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 355-390 amino acids from the C-terminal region of human NACC1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNACC1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NACC1
Synonyms BTBD14B, NAC1
Function Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.
Cellular Location Nucleus. Cytoplasm. Note=Distribution in the cytoplasm is dependent on phosphorylation.
Tissue Location Overexpressed in several types of carcinomas including ovarian serous carcinomas. Expression levels positively correlate with tumor recurrence in ovarian serous carcinomas, and intense immunoreactivity in primary ovarian tumors predicts early recurrence. Up-regulated in ovarian carcinomas after chemotherapy, suggesting a role in development of chemotherapy resistance in ovarian cancer.
Research Areas
Citations (0)

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Background

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines.

References

Cha X.Y.,et al.Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
Nakayama K.,et al.Proc. Natl. Acad. Sci. U.S.A. 103:18739-18744(2006).
Nakayama K.,et al.Cancer Res. 67:8058-8064(2007).
Davidson B.,et al.Hum. Pathol. 38:1030-1036(2007).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 295.00
$ 99.00
Cat# AP21107a
Size:
Quantity:
(40 western blots)
Availability: In Stock
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