|Application ||WB, E|
|Calculated MW||45009 Da|
|Other Names||POC1 centriolar protein homolog A, Pix2, Proteome of centriole protein 1A, WD repeat-containing protein 51A, POC1A, WDR51A|
|Target/Specificity||This POC1A antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 326-360 amino acids from the C-terminal region of human POC1A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||POC1A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole Note=Component of both mother and daughter centrioles|
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Provided below are standard protocols that you may find useful for product applications.
Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1B to ensure centriole integrity and proper mitotic spindle formation.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Hames R.S.,et al.Exp. Cell Res. 314:574-589(2008).
Pearson C.G.,et al.J. Cell Biol. 187:905-920(2009).
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