|Application ||WB, E|
|Calculated MW||158457 Da|
|Other Names||Netrin receptor DCC, Colorectal cancer suppressor, Immunoglobulin superfamily DCC subclass member 1, Tumor suppressor protein DCC, DCC, IGDCC1|
|Target/Specificity||This DCC antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1048-1082 amino acids from the C-terminal region of human DCC.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DCC Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells|
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Provided below are standard protocols that you may find useful for product applications.
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Hedrick L.,et al.Genes Dev. 8:1174-1183(1994).
Nusbaum C.,et al.Nature 437:551-555(2005).
Fearon E.R.,et al.Science 247:49-56(1990).
Nigro J.M.,et al.Cell 64:607-613(1991).
Cho K.R.,et al.Genomics 19:525-531(1994).
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