|Application ||WB, E|
|Calculated MW||52858 Da|
|Other Names||Cannabinoid receptor 1, CB-R, CB1, CANN6, CNR1, CNR|
|Target/Specificity||This CNR1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 433-468 amino acids from the C-terminal region of human CNR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNR1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.
Gerard C.,et al.Nucleic Acids Res. 18:7142-7142(1990).
Gerard C.,et al.Biochem. J. 279:129-134(1991).
Shire D.,et al.J. Biol. Chem. 270:3726-3731(1995).
Ryberg E.,et al.FEBS Lett. 579:259-264(2005).
Kathmann M.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
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