|Application ||WB, E|
|Calculated MW||99290 Da|
|Other Names||Rab GTPase-binding effector protein 1, Rabaptin-4, Rabaptin-5, Rabaptin-5alpha, Renal carcinoma antigen NY-REN-17, RABEP1, RAB5EP, RABPT5, RABPT5A|
|Target/Specificity||This RABEP1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 427-461 amino acids from the Central region of human RABEP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RABEP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||RAB5EP, RABPT5, RABPT5A|
|Function||Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Stimulates RABGEF1 mediated nucleotide exchange on RAB5A.|
|Cellular Location||Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle|
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Provided below are standard protocols that you may find useful for product applications.
Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A.
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Ota T.,et al.Nat. Genet. 36:40-45(2004).
Lubec G.,et al.Submitted (DEC-2008) to UniProtKB.
Horiuchi H.,et al.Cell 90:1149-1159(1997).
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