|Application ||WB, E|
|Calculated MW||40418 Da|
|Other Names||Protein Wnt-2, Int-1-like protein 1, Int-1-related protein, IRP, WNT2, INT1L1, IRP|
|Target/Specificity||This WNT2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 254-287 amino acids from the Central region of human WNT2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||WNT2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed:20018874). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
|Tissue Location||Expressed in brain in the thalamus, in fetal and adult lung and in placenta.|
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Provided below are standard protocols that you may find useful for product applications.
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.
Wainwright B.J.,et al.EMBO J. 7:1743-1748(1988).
Farrall M.,et al.Submitted (APR-1988) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 424:157-164(2003).
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