|Application ||WB, E|
|Calculated MW||27325 Da|
|Other Names||Chymase, Alpha-chymase, Mast cell protease I, CMA1, CYH, CYM|
|Target/Specificity||This CMA1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 84-118 amino acids from human CMA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CMA1 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.|
|Cellular Location||Secreted. Cytoplasmic granule. Note=Mast cell granules|
|Tissue Location||Mast cells in lung, heart, skin and placenta. Expressed in both normal skin and in urticaria pigmentosa lesions|
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Provided below are standard protocols that you may find useful for product applications.
Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
Caughey G.H.,et al.J. Biol. Chem. 266:12956-12963(1991).
Urata H.,et al.J. Biol. Chem. 266:17173-17179(1991).
Schechter N.M.,et al.J. Immunol. 152:4062-4069(1994).
Goshima N.,et al.Nat. Methods 5:1011-1017(2008).
Heilig R.,et al.Nature 421:601-607(2003).
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