|Application ||WB, IHC-P, E|
|Calculated MW||70841 Da|
|Antigen Region||1-30 aa|
|Other Names||Ubiquilin-3, UBQLN3|
|Target/Specificity||This Ubiquilin3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human Ubiquilin3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Ubiquilin3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Testis specific.|
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Provided below are standard protocols that you may find useful for product applications.
Ubiquilin 3 shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and are thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. The gene is specifically expressed in the testis, and proposed to regulate cell-cycle progression during spermatogenesis.
Conklin, D., et al., Gene 249 (1-2), 91-98 (2000).
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