|Application ||WB, E|
|Calculated MW||91952 Da|
|Other Names||Cytosolic phospholipase A2 delta, cPLA2-delta, Phospholipase A2 group IVD, PLA2G4D|
|Target/Specificity||This PLA2G4D antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 754-786 amino acids from human PLA2G4D.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLA2G4D Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.|
|Cellular Location||Cytoplasm, cytosol. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Translocates to membrane vesicles in a calcium-dependent fashion. Translocates to perinuclear regions upon ionomycin stimulation (By similarity)|
|Tissue Location||Expressed in stratified squamous epithelia, such as those in skin and cervix, but not in other tissues Strongly expressed in the upper spinous layer of the psoriatic epidermis, expressed weakly and discontinuously in atopic dermatitis and mycosis fungoides, and not detected in the epidermis of normal skin.|
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Provided below are standard protocols that you may find useful for product applications.
Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.
Chiba H.,et al.J. Biol. Chem. 279:12890-12897(2004).
Zody M.C.,et al.Nature 440:671-675(2006).
Tao R.,et al.Prostaglandins Leukot. Essent. Fatty Acids 73:419-422(2005).
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