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OPHN1 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - OPHN1 Antibody (Center) AP21819c
    All lanes : Anti-OPHN1 Antibody (Center) at 1:1000 dilution Lane 1: HepG2 whole cell lysate Lane 2: MDA-MB-468 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 92 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O60890
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 91641 Da
Additional Information
Gene ID 4983
Other Names Oligophrenin-1, OPHN1
Target/Specificity This OPHN1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 284-315 amino acids from the Central region of human OPHN1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsOPHN1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OPHN1
Function Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity).
Cellular Location Cell junction, synapse. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Cytoplasm. Note=Present in both presynaptic and postsynaptic sites.
Tissue Location Expressed in brain.
Research Areas
Citations (0)

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Background

Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity).

References

Billuart P.,et al.Nature 392:923-926(1998).
Tentler D.,et al.Eur. J. Hum. Genet. 7:541-548(1999).
Billuart P.,et al.Ann. Genet. 43:5-9(2000).
Kitano T.,et al.Mol. Biol. Evol. 20:1281-1289(2003).
Ross M.T.,et al.Nature 434:325-337(2005).

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$ 295.00
$ 99.00
Cat# AP21819c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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