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Epsin2 Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
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  • WB - Epsin2 Antibody (N-term) AP2182a
    All lanes : Anti-Epsin2/1 Antibody (N-term) at 1:1000 dilution Lane 1: U-87 MG whole cell lysate Lane 2: SH-SY5Y whole cell lysate Lane 3: A549 whole cell lysate Lane 4: A431 whole cell lysate Lane 5: NIH/3T3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 68 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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  • WB - Epsin2 Antibody (N-term) AP2182a
    The anti-Epsin2 Pab (Cat. #AP2182a) is used in Western blot to detect Epsin2 in mouse brain tissue lysate.
    detail
  • IHC-P - Epsin2 Antibody (N-term) AP2182a
    Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
    detail
  • SPECIFICATION
  • CITATIONS: 1
  • PROTOCOLS
  • BACKGROUND
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O95208
Other Accession Q9Z1Z3, Q8CHU3, O88339, Q80VP1, Q9Y6I3, Q8IYW4
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 68482 Da
Antigen Region 6-36 aa
Additional Information
Gene ID 22905
Other Names Epsin-2, EPS-15-interacting protein 2, EPN2, KIAA1065
Target/Specificity This Epsin2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-36 amino acids from the N-terminal region of human Epsin2.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEpsin2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPN2
Synonyms KIAA1065
Function Plays a role in the formation of clathrin-coated invaginations and endocytosis.
Cellular Location Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle. Note=In punctate structures throughout the cell, associated with clathrin-coated vesicles, and particularly concentrated in the region of the Golgi complex
Tissue Location Highest expression is found in brain. Detected at lower levels in lung and liver.
Research Areas
Citations ( 0 )

Background

Epsin2 plays a role in the formation of clathrin-coated invaginations and endocytosis. It binds to EPS15 (via the NPF repeat domain), as well as to AP-2 and clathrin (via the DPW repeat domain). The protein resides in the cytoplasm, in punctate structures throughout the cell, associated with clathrin-coated vesicles, and is particularly concentrated in the region of the Golgi complex. Highest expression is found in brain, with lower levels detected in lung and liver.

References

Ota, T., et al., Nat. Genet. 36(1):40-45 (2004).
Kikuno, R., et al., DNA Res. 6(3):197-205 (1999).
Rosenthal, J.A., et al., J. Biol. Chem. 274(48):33959-33965 (1999).

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$ 365.00
$ 140.00
Cat# AP2182a
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