|Application ||WB, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||27399 Da|
|Other Names||Fibroblast growth factor 12, FGF-12, Fibroblast growth factor homologous factor 1, FHF-1, Myocyte-activating factor, FGF12, FGF12B, FHF1|
|Target/Specificity||This FGF12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 159-191 amino acids from the Central region of human FGF12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FGF12 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.|
|Tissue Location||Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Probably involved in nervous system development and function.
Smallwood P.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
Kok L.D.S.,et al.Biochem. Biophys. Res. Commun. 255:717-721(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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