|Application ||WB, E|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||27399 Da|
|Other Names||Fibroblast growth factor 12, FGF-12, Fibroblast growth factor homologous factor 1, FHF-1, Myocyte-activating factor, FGF12, FGF12B, FHF1|
|Target/Specificity||This FGF12 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 159-191 amino acids from the Central region of human FGF12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FGF12 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.|
|Tissue Location||Brain, eye and testis; highly expressed in embryonic retina, olfactory epithelium, olfactory bulb, and in a segmental pattern of the body wall; in adult olfactory bulb, less in cerebellum, deep cerebellar nuclei, cortex and multiple midbrain structures|
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Provided below are standard protocols that you may find useful for product applications.
Probably involved in nervous system development and function.
Smallwood P.M.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
Kok L.D.S.,et al.Biochem. Biophys. Res. Commun. 255:717-721(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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