FXC1 Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9Y5J6 |
Other Accession | Q3SZW4, Q9WV96, Q5RDJ0, Q9R1B1 |
Reactivity | Human, Rat |
Predicted | Bovine, Mouse |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 11586 Da |
Gene ID | 26515 |
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Other Names | Mitochondrial import inner membrane translocase subunit Tim10 B, Fracture callus protein 1, FxC1, Mitochondrial import inner membrane translocase subunit Tim9 B, TIMM10B, Tim10b, TIMM10B, FXC1, TIM9B, TIMM9B |
Target/Specificity | This FXC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 15-48 amino acids from the N-terminal region of human FXC1. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | FXC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TIMM10B |
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Synonyms | FXC1, TIM9B, TIMM9B |
Function | Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space. |
Cellular Location | Mitochondrion inner membrane; Peripheral membrane protein |
Tissue Location | Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin- pore translocase that uses the membrane potential as the external driving force. In the TIM22 complex, it may act as a docking point for the soluble 70 kDa complex that guides the target proteins in transit through the aqueous mitochondrial intermembrane space.
References
Jin H.,et al.Genomics 61:259-267(1999).
Bauer M.F.,et al.FEBS Lett. 464:41-47(1999).
Peng Y.,et al.Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
Rothbauer U.,et al.J. Biol. Chem. 276:37327-37334(2001).
Muehlenbein N.,et al.J. Biol. Chem. 279:13540-13546(2004).
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