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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   DEDD2 Antibody (Center)   

DEDD2 Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DEDD2 Antibody (Center) AP21912c
    Anti-DEDD2 Antibody (Center) at 1:2000 dilution + SW480 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 36 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8WXF8
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 36179 Da
Additional Information
Gene ID 162989
Other Names DNA-binding death effector domain-containing protein 2, DED-containing protein FLAME-3, FADD-like anti-apoptotic molecule 3, DEDD2, FLAME3
Target/Specificity This DEDD2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-193 amino acids from the Central region of human DEDD2.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDEDD2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DEDD2
Synonyms FLAME3
Function May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.
Cellular Location Nucleus, nucleolus. Note=Nuclear, accumulated in subnuclear structures resembling nucleoli
Tissue Location Expressed in most tissues. High levels were found in liver, kidney, heart, ovary, spleen, testes, skeletal muscle and peripheral blood leukocytes. Expression was absent or low in colon and small intestine. Expression is relatively high in the tumor cell lines chronic myologenous leukemia K-562 and the colorectal adenocarcinoma SW480. Expression is moderate in the cervical carcinoma HeLa, the Burkitt's lymphoma Raji, the lung carcinoma A-549, and the melanoma G-361. In contrast, two leukemia cell lines, HL-60 (promyelocytic leukemia) and MOLT-4 (lymphoblastic leukemia), show relatively low levels
Research Areas
Citations (0)

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Background

May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3.

References

Roth W.,et al.J. Biol. Chem. 277:7501-7508(2002).
Zhan Y.,et al.Cell Death Differ. 9:439-447(2002).
Lee J.C.,et al.J. Cell Biol. 158:1051-1066(2002).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Alcivar A.,et al.Oncogene 22:291-297(2003).

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$ 99.00
Cat# AP21912c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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