SPTBN1 Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q62261 |
Other Accession | Q01082 |
Reactivity | Mouse |
Predicted | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 274223 Da |
Gene ID | 20742 |
---|---|
Other Names | Spectrin beta chain, non-erythrocytic 1, Beta-II spectrin, Fodrin beta chain, Spectrin, non-erythroid beta chain 1, SPTBN1, SPTB2 |
Target/Specificity | This SPTBN1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 2063-2097 amino acids from mouse SPTBN1. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SPTBN1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | Sptbn1 |
---|---|
Synonyms | Elf, Spnb-2, Spnb2, Sptb2 |
Function | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. |
Cellular Location | Cytoplasm, cytoskeleton. Endomembrane system. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q01082}. Cell membrane {ECO:0000250|UniProtKB:Q01082}. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes |
Tissue Location | Isoform 2 is present in brain, heart, kidney and liver (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
References
Hu R.J.,et al.J. Biol. Chem. 267:18715-18722(1992).
Chen Y.,et al.J. Mol. Neurosci. 17:59-70(2001).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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