|Application ||WB, E|
|Calculated MW||73969 Da|
|Other Names||PML-RARA-regulated adapter molecule 1, PRAM, PRAM-1, PRAM1|
|Target/Specificity||This PRAM1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 587-618 amino acids from human PRAM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRAM1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.|
|Tissue Location||Expressed in peripheral blood leukocytes and bone marrow. Expressed in monocytes, and to a lesser extent in granulocytes and lymphocytes. Not expressed in non hematopoietic tissues except in lung.|
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May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
Moog-Lutz C.,et al.J. Biol. Chem. 276:22375-22381(2001).
Grimwood J.,et al.Nature 428:529-535(2004).
Denis F.M.,et al.J. Biol. Chem. 280:9043-9048(2005).
Heuer K.,et al.J. Mol. Biol. 361:94-104(2006).
Choudhary C.,et al.Science 325:834-840(2009).
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