|Application ||WB, E|
|Calculated MW||79245 Da|
|Other Names||PML-RARA-regulated adapter molecule 1, PRAM, PRAM-1, PRAM1|
|Target/Specificity||This PRAM1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 587-618 amino acids from human PRAM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRAM1 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.|
|Tissue Location||Expressed in peripheral blood leukocytes and bone marrow. Expressed in monocytes, and to a lesser extent in granulocytes and lymphocytes. Not expressed in non hematopoietic tissues except in lung.|
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Provided below are standard protocols that you may find useful for product applications.
May be involved in myeloid differentiation. May be involved in integrin signaling in neutrophils. Binds to PtdIns(4)P.
Moog-Lutz C.,et al.J. Biol. Chem. 276:22375-22381(2001).
Grimwood J.,et al.Nature 428:529-535(2004).
Denis F.M.,et al.J. Biol. Chem. 280:9043-9048(2005).
Heuer K.,et al.J. Mol. Biol. 361:94-104(2006).
Choudhary C.,et al.Science 325:834-840(2009).
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