|Application ||WB, E|
|Calculated MW||32419 Da|
|Other Names||Protein HEXIM2, Hexamethylene bis-acetamide-inducible protein 2, HEXIM2|
|Target/Specificity||This HEXIM2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 235-269 amino acids from of human HEXIM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HEXIM2 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.|
|Tissue Location||Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed|
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Provided below are standard protocols that you may find useful for product applications.
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Petroziello J.,et al.Oncogene 23:7734-7745(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Byers S.A.,et al.J. Biol. Chem. 280:16360-16367(2005).
Yik J.H.N.,et al.J. Biol. Chem. 280:16368-16376(2005).
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