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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Klotho Antibody (C-term)   

Klotho Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Klotho Antibody (C-term) AP22140b
    All lanes : Anti-Klotho Antibody (C-term) at 1:2000 dilution Lane 1: human testis lysate Lane 2: 293 whole cell lysate Lane 3: HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 116 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UEF7
Other Accession Q8WP17
Reactivity Human
Host Rabbit
Clonality polyclonal
Isotype Rabbit Ig
Calculated MW 116181 Da
Additional Information
Gene ID 9365
Other Names Klotho, 3.2.1.31, Klotho peptide, KL
Target/Specificity This Klotho antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 284-315 amino acids from the C-terminal region of human Klotho.
Dilution WB~~1:2000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKlotho Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KL
Function May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).
Cellular Location Isoform 1: Cell membrane; Single-pass type I membrane protein. Apical cell membrane {ECO:0000250|UniProtKB:O35082}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O35082}. Note=Isoform 1 shedding leads to a soluble peptide {ECO:0000250|UniProtKB:O35082} Klotho peptide: Secreted {ECO:0000250|UniProtKB:O35082}
Tissue Location Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney
Research Areas
Citations (0)

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Background

May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).

References

Kuro-o M.,et al.Nature 390:45-51(1997).
Matsumura Y.,et al.Biochem. Biophys. Res. Commun. 242:626-630(1998).
Dunham A.,et al.Nature 428:522-528(2004).
Kato Y.,et al.Biochem. Biophys. Res. Commun. 267:597-602(2000).
Yahata K.,et al.J. Mol. Med. 78:389-394(2000).

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$ 295.00
$ 99.00
Cat# AP22140b
Size:
Quantity:
(40 western blots)
Availability: In Stock
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