SH3BP5 Antibody (N-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O60239 |
Reactivity | Human |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 50425 Da |
Gene ID | 9467 |
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Other Names | SH3 domain-binding protein 5, SH3BP-5, SH3 domain-binding protein that preferentially associates with BTK, SH3BP5, SAB |
Target/Specificity | This SH3BP5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 63-97 amino acids from human SH3BP5. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SH3BP5 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SH3BP5 |
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Synonyms | SAB |
Function | Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B- cells. May be involved in BCR-induced apoptotic cell death. |
Cellular Location | Cytoplasmic vesicle membrane; Peripheral membrane protein. Mitochondrion. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes. |
Tissue Location | Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
References
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Matsushita M.,et al.Biochem. Biophys. Res. Commun. 245:337-343(1998).
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