|Application ||WB, E|
|Calculated MW||50425 Da|
|Other Names||SH3 domain-binding protein 5, SH3BP-5, SH3 domain-binding protein that preferentially associates with BTK, SH3BP5, SAB|
|Target/Specificity||This SH3BP5 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 63-97 amino acids from human SH3BP5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SH3BP5 Antibody (N-Term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.|
|Tissue Location||Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.|
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Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Matsushita M.,et al.Biochem. Biophys. Res. Commun. 245:337-343(1998).
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