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PEPD Antibody (C-Term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P12955 |
| Other Accession | Q11136, Q5RFB3, Q5I0D7 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 54548 Da |
| Gene ID | 5184 |
|---|---|
| Other Names | Xaa-Pro dipeptidase, X-Pro dipeptidase, 3.4.13.9, Imidodipeptidase, Peptidase D, Proline dipeptidase, Prolidase, PEPD, PRD |
| Target/Specificity | This PEPD antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 364-398 amino acids from human PEPD. |
| Dilution | WB~~1:2000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PEPD Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PEPD {ECO:0000303|PubMed:8198124, ECO:0000312|HGNC:HGNC:8840} |
|---|---|
| Function | Dipeptidase that catalyzes the hydrolysis of dipeptides with a prolyl (Xaa-Pro) or hydroxyprolyl residue in the C-terminal position (PubMed:17081196, PubMed:35165443). The preferred dipeptide substrate is Gly-Pro, but other Xaa-Pro dipeptides, such as Ala-Pro, Met-Pro, Phe-Pro, Val-Pro and Leu-Pro, can be cleaved (PubMed:17081196). Plays an important role in collagen metabolism because the high level of iminoacids in collagen (PubMed:2925654). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
References
Endo F.,et al.J. Biol. Chem. 264:4476-4481(1989).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Grimwood J.,et al.Nature 428:529-535(2004).
Harris R.A.,et al.Proteomics 2:212-223(2002).
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