|Application ||WB, E|
|Calculated MW||101579 Da|
|Target/Specificity||This SH3PXD2B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 505-539 amino acids from the Central region of human SH3PXD2B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SH3PXD2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FAD49, KIAA1295, TKS4|
|Function||Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity).|
|Cellular Location||Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.|
|Tissue Location||Expressed in fibroblasts.|
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