CHRNE Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, FC, E |
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Primary Accession | Q04844 |
Other Accession | P20782, P09660 |
Reactivity | Human, Mouse, Rat |
Predicted | Mouse, Rat |
Host | Rabbit |
Clonality | polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 54697 Da |
Gene ID | 1145 |
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Other Names | Acetylcholine receptor subunit epsilon, CHRNE, ACHRE |
Target/Specificity | This CHRNE antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 409-443 amino acids from the Central region of human CHRNE. |
Dilution | WB~~1:2000 FC~~1:25 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CHRNE Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CHRNE (HGNC:1966) |
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Synonyms | ACHRE |
Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. |
Cellular Location | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
References
Beeson D.M.W.,et al.Eur. J. Biochem. 215:229-238(1993).
Abicht A.,et al.Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Gomez C.M.,et al.Neurology 45:982-985(1995).
Ohno K.,et al.Proc. Natl. Acad. Sci. U.S.A. 92:758-762(1995).
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