|Application ||WB, E|
|Calculated MW||111249 Da|
|Other Names||Bone morphogenetic protein 1, BMP-1, 22.214.171.124, Mammalian tolloid protein, mTld, Procollagen C-proteinase, PCP, BMP1, PCOLC|
|Target/Specificity||This BMP1 antibody is generated from a rabbit immunized with a recombinant protein of human BMP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BMP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.|
|Cellular Location||Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Note=Co- localizes with POSTN in the Golgi.|
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Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX.
Li S.W.,et al.Proc. Natl. Acad. Sci. U.S.A. 93:5127-5130(1996).
Wozney J.M.,et al.Science 242:1528-1534(1988).
Janitz M.,et al.J. Mol. Med. 76:141-146(1998).
Takahara K.,et al.J. Biol. Chem. 269:32572-32578(1994).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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